Physical deformity and the cause of death
"More recently Alexander’s physical characteristics have been combined with the information of his final days to arrive at the cause of his death. Many descriptions and statues typically portray Alexander with a cervical neck deformity, typically with a gaze looking upward and outward (an image still used in modern day heroic photography). Both his father Philip II and his brother Philip Arridaeus also suffered from physical deformities, leading some to suggest a congenital scoliotic disorder (familial neck and spinal deformity). A familial scoliotic deformity has therefore been ascribed as the cause of his death by means of an ascending spinal infection (pyogenic spondylitis or meningitis), which would also explain the ascending spinal paralysis in his final days. Furthermore, such a condition has also been proposed as a potential cause for Alexander’s depictions with horns by way of a scoliosis associated neurocutaneous Epidermal Nevus Syndrome."
Yeah, that's from Wikipedia, so take that into consideration. But still, something to think about.